KLOW Peptide Blend

What Is in the KLOW Peptide Blend?

KLOW is GLOW plus KPV. The full breakdown, published:

As with GLOW, GHK-Cu dominates by mass — 63% of the blend. Most vendors don’t publish that. A buyer who doesn’t know the ratio doesn’t know what they’re buying.

What the KPV Peptide Adds: The Inflammation Arm

KPV is the reason KLOW exists as a separate product, and it is genuinely interesting.

KPV is a tripeptide — Lys-Pro-Val. Three amino acids. And it is the C-terminal fragment of α-MSH, the melanocortin hormone.

The elegant part: KPV has no melanocortin receptor activity

Full α-MSH binds melanocortin receptors — including MC1R, which drives melanogenesis. That’s the mechanism behind Melanotan 2.

KPV does not. The three-residue C-terminal fragment carries α-MSH’s anti-inflammatory activity without its receptor binding. It works through a different route entirely: inhibition of NF-κB signalling — the master transcriptional regulator of the inflammatory response.

It is α-MSH’s anti-inflammatory half, with the pigmentation half removed.

The same design logic that produced PT-141 out of Melanotan 2, and Semax out of ACTH: take a hormone, keep the part you want, drop the receptor you don’t.

The Four Mechanisms

KLOW targets four distinct points in the repair process:

• GHK-Cu — the matrix. Copper delivery for lysyl oxidase (collagen cross-linking) and superoxide dismutase. Broad transcriptional modulation — roughly 4,048 human genes.
• BPC-157 — the supply route. VEGF-mediated angiogenesis; builds the vascular access to a damaged site.
• TB-500 — the workforce. Actin sequestration; moves repair cells to that site.
• KPV — the brake on inflammation. NF-κB inhibition; modulates the inflammatory response that repair happens inside of.

Substrate, supply, migration, and inflammation. That is the research rationale for the four-component formulation.

What the Research Reports

Each component has its own literature. There is no research on this specific four-compound blend — it is a commercial formulation, not a studied intervention.

GHK-Cu — modulation of ~4,048 human genes; collagen synthesis; antioxidant activity via superoxide dismutase.

BPC-157 — tendon repair via the FAK-paxillin pathway (Chang et al., 2011); gastric mucosal protection; VEGF angiogenesis.

TB-500 — wound closure; cardiomyocyte migration; corneal epithelial repair.

KPV — anti-inflammatory activity via NF-κB inhibition, in models of intestinal and dermal inflammation. Notably without melanocortin receptor activity.

All findings are preclinical. KPV was on the FDA’s Category 2 restricted list from 2023; the restriction was lifted in 2026.

KLOW Peptide Dosage in the Published Research

Four compounds, four separate literatures, four separate quantities. There is no published research on this blend and no combined figure exists.

See the individual product pages: GHK-Cu · TB-500 · BPC-157.

CompoundPlug provides no dosing recommendations.

Is KLOW Legal in Canada?

None of the four components is an authorized health product in Canada. None carries a DIN or NPN. None is a controlled substance under the CDSA.

Note: topical cosmetic formulations containing GHK-Cu exist in the consumer market and are regulated separately. CompoundPlug does not supply cosmetic products and makes no cosmetic claims.

See Research Use Only.

Reconstitution & Storage

All four compounds are water-soluble and reconstitute together in the same bacteriostatic water. Add slowly down the vial wall, swirl, never vortex.

The solution will be blue — copper(II) from the GHK-Cu, which is 63% of the blend. Expected and correct.

Molar calculations must be run per component. The four molecular weights span from ~355 (KPV) to 4963.44 (TB-500) — a factor of fourteen. There is no single blend molarity.

Storage: lyophilized and sealed, up to 24 months. Reconstituted, 2–8 °C, 3–4 weeks, protected from light.

KLOW calculator — run each component · Reconstitution guide

Quality & Verification

Independent HPLC and mass-spec testing on all four compounds, published rather than asserted.

Four components means four ways to get identity wrong.

Is the GHK-Cu the copper complex (403.93) or free GHK (340.38)? Copper is the mechanism.

Is the TB-500 full-length Thymosin Beta-4 (4963.44) or the 7-residue fragment (~878)? Five times the mass, same name.

A purity test cannot answer either question. Mass spectrometry measures molecular weight directly — and on a four-component blend, it is the only test that confirms all four molecules are present and correct.

CompoundPlug supplies the copper complex and full-length Thymosin Beta-4, and publishes the molecular weight of every component. Vials measured by peptide content. Published analysis in the COA Library.

Buy the KLOW Blend in Canada

Research-grade KLOW — GHK-Cu 50mg + BPC-157 10mg + TB-500 10mg + KPV 10mg, 80mg total. ≥99% HPLC purity, all four components mass-spec verified, published reference COA.

• Full component breakdown published — including that GHK-Cu is 63% of the blend
• All four molecular weights published
• Ships from within Canada — Canada Post Xpresspost, tracked
• CAD pricing · Interac e-Transfer or crypto · discreet packaging

Related: GLOW — the same blend without KPV. Individual components: GHK-Cu · TB-500 · BPC-157. Browse Healing Peptides.

Frequently Asked Questions